RESUMO
The pharmacokinetic characteristics of APP were studied in 10 male New Zealand rabbits. An initial dose of 15,000 IU of APP per kg of weight was administered. The respective fibrinolytic activity was estimated by fibrin plates and transformed according to theoretical considerations. Knorre's criterion was used for the determination of the number of compartments. In every case the values were below 0.2 which indicates a one-compartment open model. The data were fitted to the proposed model in two steps; first the stripping method was used, afterwards the values obtained by the stripping were used as initial values for nonlinear fitting by means of nonlin programs.
Assuntos
Ativadores de Plasminogênio/farmacocinética , Absorção , Animais , Esquema de Medicação , Meia-Vida , Injeções Intravenosas , Masculino , Taxa de Depuração Metabólica , Modelos Biológicos , Ativadores de Plasminogênio/administração & dosagem , Ativadores de Plasminogênio/sangue , CoelhosRESUMO
El presente trabajo se estudio el efecto del ergocomb en una serie de 15 pacientes diabeticos con pie diabetico neuroinfeccioso con componente isquemico a los cuales se les midio el flujo basal, en hiperemia maxima mediante pletismografia por oclusion venosa con transductores de mercurio, ademas, se midio la resistencia basal, en hiperemia maxima, la tension arterial sistolica y diastolica, antes e inmediatamente despues de la administracion de la droga por via intrarterial femoral y se encontro diferencia significativa para los parametros flujo y resistencia, no asi para la presion arterial
Assuntos
Humanos , Antagonistas Adrenérgicos alfa , Diabetes MellitusRESUMO
En una muestra de diez pacientes se investigo los efectos de una nueva droga vasodilatadora sobre la presion arterial, frecuencia cardiaca, asi como su efecto sobre los intervalos PR, QTc y el complejo QRS.Esta droga redujo la presion arterial, la frecuencia cardiaca y prolongo los intervalos RR y QTc del electrocardiograma
